Product Data Sheet
Riviciclib
Catalog No. A54287
Riviciclib is a potent cyclin-dependent kinase (CDK) inhibitor that selectively targets CDK9-cyclin T1, CDK4-cyclin D1, and CDK1-cyclin B, exhibiting IC50 values of 20 nM, 63 nM, and 79 nM, respectively. This compound demonstrates significant antitumor activity, especially in cisplatin-resistant cancer cells. Riviciclib is useful for research applications focused on cell cycle regulation, cancer therapy, and the development of resistance to chemotherapeutics.
Chemical Information
| Catalog Num | A54287 |
|---|---|
| M. Wt | 401.84 |
| Formula | C21H20ClNO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 920113-02-6 |
| Synonyms | P276-00 free base |
| SMILES | O=C1C=C(C2=C(Cl)C=CC=C2)OC3=C([C@H]4[C@H](CO)N(C)CC4)C(O)=CC(O)=C13 |
Biological Activity
| Description | Riviciclib is a potent cyclin-dependent kinase (CDK) inhibitor that selectively targets CDK9-cyclin T1, CDK4-cyclin D1, and CDK1-cyclin B, exhibiting IC50 values of 20 nM, 63 nM, and 79 nM, respectively. This compound demonstrates significant antitumor activity, especially in cisplatin-resistant cancer cells. Riviciclib is useful for research applications focused on cell cycle regulation, cancer therapy, and the development of resistance to chemotherapeutics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
