Product Data Sheet
CDK8-IN-6
Catalog No. A54298
CDK8-IN-6 is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) with a Kd of 13 nM. This compound exhibits significant cytotoxic effects on various cancer cell lines, including MOLM-13, OCI-AML3, MV4-11, NRK, and H9c2, with IC50 values ranging from 7.5 to 25 µM. CDK8-IN-6 holds promise for advancing research in acute myeloid leukemia (AML) and related cancer studies, making it a valuable tool for investigating CDK8's role in tumorigenesis.
Chemical Information
| Catalog Num | A54298 |
|---|---|
| M. Wt | 413.04 |
| Formula | C26H37ClN2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2415156-27-1 |
| Synonyms | |
| SMILES | C[C@@]12C(C3=CC(Cl)=CN=C3)=CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](N(C)C)CC[C@]5(C)[C@@]4([H])CC2 |
Biological Activity
| Description | CDK8-IN-6 is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) with a Kd of 13 nM. This compound exhibits significant cytotoxic effects on various cancer cell lines, including MOLM-13, OCI-AML3, MV4-11, NRK, and H9c2, with IC50 values ranging from 7.5 to 25 µM. CDK8-IN-6 holds promise for advancing research in acute myeloid leukemia (AML) and related cancer studies, making it a valuable tool for investigating CDK8's role in tumorigenesis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
