Product Data Sheet
PF-06842874
Catalog No. A54312
PF-06842874 is a selective inhibitor of CDK4 and CDK6, targeting the cyclin D1 and cyclin D3 complexes with Ki values of 62 nM and 130 nM, respectively. This compound demonstrates significant biological activity in the inhibition of cell proliferation, making it a valuable tool in cancer research and the study of pulmonary arterial hypertension. Its ability to modulate cell cycle progression positions PF-06842874 as an important reagent for investigating therapeutic strategies in oncological and vascular disease contexts.
Chemical Information
| Catalog Num | A54312 |
|---|---|
| M. Wt | 385.46 |
| Formula | C21H27N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2516247-98-4 |
| Synonyms | |
| SMILES | O=C1N(C2CCCC2)C3=CC(N[C@H]4[C@@H](COCC4)O)=NC=C3C(C)=C1C(C)=O |
Biological Activity
| Description | PF-06842874 is a selective inhibitor of CDK4 and CDK6, targeting the cyclin D1 and cyclin D3 complexes with Ki values of 62 nM and 130 nM, respectively. This compound demonstrates significant biological activity in the inhibition of cell proliferation, making it a valuable tool in cancer research and the study of pulmonary arterial hypertension. Its ability to modulate cell cycle progression positions PF-06842874 as an important reagent for investigating therapeutic strategies in oncological and vascular disease contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
