Product Data Sheet
CDK4/6-IN-21 maleate
Catalog No. A54321
CDK4/6-IN-21 maleate is a potent inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), exhibiting IC50 values of 3.88 nM and 3.31 nM against CDK4 and CDK6, respectively. This compound demonstrates significant antitumor activity, making it a valuable tool for research into cell cycle regulation and cancer therapeutics. Its targeted inhibition of CDK4/6 positions it as a key reagent for studying oncogenic pathways and developing new cancer treatment strategies.
Chemical Information
| Catalog Num | A54321 |
|---|---|
| M. Wt | 620.65 |
| Formula | C31H34F2N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2765997-88-2 |
| Synonyms | |
| SMILES | OC(/C=C\C(O)=O)=O.CC(N(C1CC1)C2=CC(C3=NC(NC4=CC=C(CN(CC5)CCN(C)C)C5=N4)=NC=C3F)=C6)=NC2=C6F |
Biological Activity
| Description | CDK4/6-IN-21 maleate is a potent inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), exhibiting IC50 values of 3.88 nM and 3.31 nM against CDK4 and CDK6, respectively. This compound demonstrates significant antitumor activity, making it a valuable tool for research into cell cycle regulation and cancer therapeutics. Its targeted inhibition of CDK4/6 positions it as a key reagent for studying oncogenic pathways and developing new cancer treatment strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
