Product Data Sheet
CDK9-IN-22
Catalog No. A54347
CDK9-IN-22 is a selective inhibitor of cyclin-dependent kinase 9 (CDK9) with an IC50 of 10.4 nM for CDK9, demonstrating significant efficacy in disrupting cellular pathways. This compound is known to induce apoptosis and promote cell cycle arrest at the G2/M phase. Additionally, CDK9-IN-22 decreases the levels of phosphorylated RNA polymerase II (S2) and CDK9 protein, exhibiting notable antiproliferative and anti-tumor properties. It is a valuable tool for research in cancer biology and therapeutic applications targeting CDK9-related pathways.
Chemical Information
| Catalog Num | A54347 |
|---|---|
| M. Wt | 485.55 |
| Formula | C28H28FN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2872677-61-5 |
| Synonyms | |
| SMILES | CN(CCNC(C1=CC=C(C=C1)NC2=NC(C3=C(C=C(C=C3)F)OCC4=CC=CC=C4)=CC=N2)=O)C |
Biological Activity
| Description | CDK9-IN-22 is a selective inhibitor of cyclin-dependent kinase 9 (CDK9) with an IC50 of 10.4 nM for CDK9, demonstrating significant efficacy in disrupting cellular pathways. This compound is known to induce apoptosis and promote cell cycle arrest at the G2/M phase. Additionally, CDK9-IN-22 decreases the levels of phosphorylated RNA polymerase II (S2) and CDK9 protein, exhibiting notable antiproliferative and anti-tumor properties. It is a valuable tool for research in cancer biology and therapeutic applications targeting CDK9-related pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
