Product Data Sheet
AMA-37
Catalog No. A54590
AMA-37 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 value of 0.27 μM for this target. In addition, it shows moderate inhibitory activity against phosphoinositide 3-kinase isoforms with IC50 values of 32 μM for p110α, 3.7 μM for p110β, and 22 μM for p110γ. This compound is suitable for research applications focusing on DNA repair mechanisms and cancer therapeutics, where modulation of DNA-PK activity may be beneficial.
Chemical Information
| Catalog Num | A54590 |
|---|---|
| M. Wt | 283.32 |
| Formula | C17H17NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 404009-46-7 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(N2CCOCC2)C=C1O)C3=CC=CC=C3 |
Biological Activity
| Description | AMA-37 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 value of 0.27 μM for this target. In addition, it shows moderate inhibitory activity against phosphoinositide 3-kinase isoforms with IC50 values of 32 μM for p110α, 3.7 μM for p110β, and 22 μM for p110γ. This compound is suitable for research applications focusing on DNA repair mechanisms and cancer therapeutics, where modulation of DNA-PK activity may be beneficial. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
