Product Data Sheet
NU-7163
Catalog No. A54610
NU-7163 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 of 0.19 μM and a Ki of 24 nM. This compound enhances the cytotoxic effects of ionizing radiation in the HeLa human tumor cell line, making it a valuable tool for research in cancer biology and therapeutic development. NU-7163 may be particularly relevant in studies exploring DNA repair mechanisms and enhancing the effectiveness of radiotherapy.
Chemical Information
| Catalog Num | A54610 |
|---|---|
| M. Wt | 295.33 |
| Formula | C18H17NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 503468-03-9 |
| Synonyms | |
| SMILES | O=C1C=C(N2CCOC(C2)C)OC3=C1C=CC4=C3C=CC=C4 |
Biological Activity
| Description | NU-7163 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), demonstrating an IC50 of 0.19 μM and a Ki of 24 nM. This compound enhances the cytotoxic effects of ionizing radiation in the HeLa human tumor cell line, making it a valuable tool for research in cancer biology and therapeutic development. NU-7163 may be particularly relevant in studies exploring DNA repair mechanisms and enhancing the effectiveness of radiotherapy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
