Product Data Sheet
MU1409
Catalog No. A54628
MU1409 is a selective inhibitor of the MRE11 nuclease, exhibiting an IC50 of 12.1 μM. Additionally, MU1409 inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. This compound plays a crucial role in modulating DNA repair mechanisms, particularly in BRCA2-deficient cells, by preventing the degradation of stalled replication forks. MU1409 shows promise for research focused on BRCA2 mutation-related cancers and the mechanisms of genomic instability.
Chemical Information
| Catalog Num | A54628 |
|---|---|
| M. Wt | 456.31 |
| Formula | C20H14BrN3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2379671-78-8 |
| Synonyms | |
| SMILES | OC1=CC(/C=C(C#N)/C(NC2=NC(CC3=CC=CC=C3)=CS2)=O)=CC(Br)=C1O |
Biological Activity
| Description | MU1409 is a selective inhibitor of the MRE11 nuclease, exhibiting an IC50 of 12.1 μM. Additionally, MU1409 inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. This compound plays a crucial role in modulating DNA repair mechanisms, particularly in BRCA2-deficient cells, by preventing the degradation of stalled replication forks. MU1409 shows promise for research focused on BRCA2 mutation-related cancers and the mechanisms of genomic instability. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
