Product Data Sheet
BRD9876
Catalog No. A54741
BRD9876 is a kinesin-5 (Eg5) inhibitor that functions by locking the protein in a conformation with enhanced microtubule binding, promoting microtubule bundling and stabilization. It specifically interacts with the tyrosine 104 residue within the α4-α6 allosteric binding pocket of Eg5, selectively inhibiting myeloma cells while sparing CD34+ hematopoietic stem cells. This compound is a valuable tool for studying the mechanisms of multiple myeloma and developing potential therapeutic strategies.
Chemical Information
| Catalog Num | A54741 |
|---|---|
| M. Wt | 234.30 |
| Formula | C16H14N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 32703-82-5 |
| Synonyms | |
| SMILES | CC(C)(C1=CC2=CC(C#N)=C(C#N)C=C2C=C1)C |
Biological Activity
| Description | BRD9876 is a kinesin-5 (Eg5) inhibitor that functions by locking the protein in a conformation with enhanced microtubule binding, promoting microtubule bundling and stabilization. It specifically interacts with the tyrosine 104 residue within the α4-α6 allosteric binding pocket of Eg5, selectively inhibiting myeloma cells while sparing CD34+ hematopoietic stem cells. This compound is a valuable tool for studying the mechanisms of multiple myeloma and developing potential therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
