Product Data Sheet
4'-Methoxy-S-trityl-L-cysteinol
Catalog No. A54773
4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor targeting vertebrate Kinesin Spindle Protein (KSP). This compound demonstrates enhanced inhibitory activity against NCI60 tumor cell lines, attributed to modifications in its trityl and cysteine groups. It exhibits an EC50 of 28 μM for bipolar spindle formation, indicating superior potency compared to its parent compound and monastrol. This makes it a valuable tool for investigating KSP's role in mitosis and potential therapeutic strategies in cancer research.
Chemical Information
| Catalog Num | A54773 |
|---|---|
| M. Wt | 379.52 |
| Formula | C23H25NO2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1338701-15-7 |
| Synonyms | |
| SMILES | OC[C@@H](N)CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=C(C=C3)OC |
Biological Activity
| Description | 4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor targeting vertebrate Kinesin Spindle Protein (KSP). This compound demonstrates enhanced inhibitory activity against NCI60 tumor cell lines, attributed to modifications in its trityl and cysteine groups. It exhibits an EC50 of 28 μM for bipolar spindle formation, indicating superior potency compared to its parent compound and monastrol. This makes it a valuable tool for investigating KSP's role in mitosis and potential therapeutic strategies in cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
