Product Data Sheet
Cys-McMMAF
Catalog No. A54808
Cys-McMMAF is the active payload derived from AlMcMMAF, a humanized A1 antibody specifically targeting the 5T4 antigen, conjugated to the microtubule-disrupting agent MMAF through a maleimidocaproyl linker. This compound demonstrates significant antitumor efficacy in mouse models, specifically H1975 and MDA-MB-361-DYT2, making it a valuable tool for cancer research and the development of targeted therapeutics. Cys-McMMAF is ideal for studies focused on antibody-drug conjugates and their potential in oncological therapies.
Chemical Information
| Catalog Num | A54808 |
|---|---|
| M. Wt | 1046.32 |
| Formula | C52H83N7O13S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1160590-05-5 |
| Synonyms | |
| SMILES | OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCCCCN3C(C(CC3=O)SC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)OC)=O)=O |
Biological Activity
| Description | Cys-McMMAF is the active payload derived from AlMcMMAF, a humanized A1 antibody specifically targeting the 5T4 antigen, conjugated to the microtubule-disrupting agent MMAF through a maleimidocaproyl linker. This compound demonstrates significant antitumor efficacy in mouse models, specifically H1975 and MDA-MB-361-DYT2, making it a valuable tool for cancer research and the development of targeted therapeutics. Cys-McMMAF is ideal for studies focused on antibody-drug conjugates and their potential in oncological therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
