Product Data Sheet
Methylene blue hydrate
Catalog No. A54811
Methylene blue hydrate is a selective inhibitor of soluble guanylyl cyclase (sGC), as well as monoamine oxidase A (MAO-A) and nitric oxide synthase (NOS). This compound exhibits significant biological activities, including the modulation of the nitric oxide syntase/guanylate cyclase signaling pathway, which results in decreased prepulse inhibition. Methylene blue hydrate also acts as a REDOX cycling agent capable of crossing the blood-brain barrier, demonstrating neuroprotective effects such as inhibition of Tau aggregation, reduction of cerebral edema, and attenuation of neuroinflammation through the modulation of microglial activation. These properties make it valuable for research in neurodegenerative diseases and neuroinflammation studies.
Chemical Information
| Catalog Num | A54811 |
|---|---|
| M. Wt | 337.87 |
| Formula | C16H18N3S.Cl.xH2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 122965-43-9 |
| Synonyms | Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate |
| SMILES | CN(C1=CC2=[S+]C3=C(C=CC(N(C)C)=C3)N=C2C=C1)C.[x].[Cl-].O |
Biological Activity
| Description | Methylene blue hydrate is a selective inhibitor of soluble guanylyl cyclase (sGC), as well as monoamine oxidase A (MAO-A) and nitric oxide synthase (NOS). This compound exhibits significant biological activities, including the modulation of the nitric oxide syntase/guanylate cyclase signaling pathway, which results in decreased prepulse inhibition. Methylene blue hydrate also acts as a REDOX cycling agent capable of crossing the blood-brain barrier, demonstrating neuroprotective effects such as inhibition of Tau aggregation, reduction of cerebral edema, and attenuation of neuroinflammation through the modulation of microglial activation. These properties make it valuable for research in neurodegenerative diseases and neuroinflammation studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
