Product Data Sheet
RGN6024
Catalog No. A54831
RGN6024 is a reversible small molecule tubulin destabilizer that effectively inhibits microtubule polymerization by targeting the colchicine binding pocket of β-tubulin. With a binding affinity of Kd = 6.7 μM as measured by surface plasmon resonance, RGN6024 induces G2/M phase arrest in glioblastoma cells and demonstrates efficacy in βIII-tubulin overexpressing cell models. Additionally, RGN6024 inhibits tumor growth in glioblastoma xenograft mouse models, making it a valuable tool for research into glioblastoma pathophysiology and therapeutic strategies.
Chemical Information
| Catalog Num | A54831 |
|---|---|
| M. Wt | 403.46 |
| Formula | C18H21N5O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3055038-20-2 |
| Synonyms | |
| SMILES | O=C(NC1=NC=C(OC2=CN=C(N=C2)N3CCOCC3)S1)C45CC(OC)(C5)C4 |
Biological Activity
| Description | RGN6024 is a reversible small molecule tubulin destabilizer that effectively inhibits microtubule polymerization by targeting the colchicine binding pocket of β-tubulin. With a binding affinity of Kd = 6.7 μM as measured by surface plasmon resonance, RGN6024 induces G2/M phase arrest in glioblastoma cells and demonstrates efficacy in βIII-tubulin overexpressing cell models. Additionally, RGN6024 inhibits tumor growth in glioblastoma xenograft mouse models, making it a valuable tool for research into glioblastoma pathophysiology and therapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
