Product Data Sheet
Tubulin/NEDDylation-IN-1
Catalog No. A54859
Tubulin/NEDDylation-IN-1 (compound C11) is a potent dual inhibitor targeting tubulin and NEDDylation, exhibiting an IC50 of 2.40 μM for tubulin. This compound effectively disrupts microtubule dynamics and inhibits the NEDDylation process, a crucial post-translational modification involving the attachment of the ubiquitin-like protein NEDD8 to target proteins. By forming hydrogen bonds with key residues in tubulin and the NEDD8 activating enzyme (NAE) through its methoxy and dithiocarbamate functionalities, Tubulin/NEDDylation-IN-1 demonstrates significant anti-proliferative activity and serves as a valuable tool for research investigating cellular proliferation and microtubule regulation.
Chemical Information
| Catalog Num | A54859 |
|---|---|
| M. Wt | 504.66 |
| Formula | C25H32N2O5S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3072778-26-5 |
| Synonyms | |
| SMILES | O=C(N(CC1=CC=C(OC)C=C1)C2=CC(OC)=C(OC)C(OC)=C2)CSC(N3CCCCC3)=S |
Biological Activity
| Description | Tubulin/NEDDylation-IN-1 (compound C11) is a potent dual inhibitor targeting tubulin and NEDDylation, exhibiting an IC50 of 2.40 μM for tubulin. This compound effectively disrupts microtubule dynamics and inhibits the NEDDylation process, a crucial post-translational modification involving the attachment of the ubiquitin-like protein NEDD8 to target proteins. By forming hydrogen bonds with key residues in tubulin and the NEDD8 activating enzyme (NAE) through its methoxy and dithiocarbamate functionalities, Tubulin/NEDDylation-IN-1 demonstrates significant anti-proliferative activity and serves as a valuable tool for research investigating cellular proliferation and microtubule regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
