Product Data Sheet
ABI-274
Catalog No. A54872
ABI-274 is a potent tubulin inhibitor that targets the colchicine binding site. This compound significantly enhances cancer cell apoptosis in vitro when used in combination with vemurafenib, exhibiting strong synergistic effects. In vivo studies demonstrate its efficacy in vemurafenib-resistant xenograft models in nude mice, making ABI-274 a critical tool for research on melanoma and potential therapeutic strategies in resistant cancer forms.
Chemical Information
| Catalog Num | A54872 |
|---|---|
| M. Wt | 352.38 |
| Formula | C20H20N2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1253697-93-6 |
| Synonyms | |
| SMILES | COC1=CC(C(C2=CN=C(C3=CC=C(C=C3)C)N2)=O)=CC(OC)=C1OC |
Biological Activity
| Description | ABI-274 is a potent tubulin inhibitor that targets the colchicine binding site. This compound significantly enhances cancer cell apoptosis in vitro when used in combination with vemurafenib, exhibiting strong synergistic effects. In vivo studies demonstrate its efficacy in vemurafenib-resistant xenograft models in nude mice, making ABI-274 a critical tool for research on melanoma and potential therapeutic strategies in resistant cancer forms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
