Product Data Sheet
Antitumor agent-200
Catalog No. A54885
Antitumor agent-200 is a microtubule synthesis inhibitor that targets the colchicine site on tubulin, leading to G2/M cell cycle arrest and the generation of reactive oxygen species (ROS). This compound demonstrates significant inhibitory activity against MCF7/ADR and KBV200 cell lines exhibiting P-glycoprotein overexpression, with drug resistance indices of 0.83 and 0.58, respectively. In vivo studies using the MCF-7 xenograft model have shown that Antitumor agent-200 at a dosage of 25 mg/kg via intraperitoneal injection results in a tumor growth inhibition rate of 57.2%. This reagent is valuable for research in the oncology field, particularly in studies related to drug resistance and cancer treatment efficacy.
Chemical Information
| Catalog Num | A54885 |
|---|---|
| M. Wt | 423.34 |
| Formula | C19H21FN2O3Se |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3046118-64-0 |
| Synonyms | |
| SMILES | FC(C=C1C(NCC2=CC=C([Se]C)C(O)=C2)=O)=CC=C1N3CCOCC3 |
Biological Activity
| Description | Antitumor agent-200 is a microtubule synthesis inhibitor that targets the colchicine site on tubulin, leading to G2/M cell cycle arrest and the generation of reactive oxygen species (ROS). This compound demonstrates significant inhibitory activity against MCF7/ADR and KBV200 cell lines exhibiting P-glycoprotein overexpression, with drug resistance indices of 0.83 and 0.58, respectively. In vivo studies using the MCF-7 xenograft model have shown that Antitumor agent-200 at a dosage of 25 mg/kg via intraperitoneal injection results in a tumor growth inhibition rate of 57.2%. This reagent is valuable for research in the oncology field, particularly in studies related to drug resistance and cancer treatment efficacy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
