Product Data Sheet
Tubulin Polymerization-IN-1 prodrug
Catalog No. A54895
Tubulin Polymerization-IN-1 prodrug is a palladium-mediated inhibitor of tubulin polymerization, developed to target the colchicine binding site. This prodrug demonstrates significantly reduced cytotoxicity compared to its parent compound, offering a 68.3-fold reduction in toxicity while maintaining effectiveness upon activation by Pd resin. Mechanistic investigations align its anticancer activity with that of colchicine binding site inhibitors. In vivo studies have shown that treatment with Tubulin Polymerization-IN-1 prodrug results in a substantial inhibition of tumor growth (63.2%) following Pd resin activation. This compound holds potential for advancing research in anticancer therapeutics.
Chemical Information
| Catalog Num | A54895 |
|---|---|
| M. Wt | 398.43 |
| Formula | C22H23FN2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3033099-32-7 |
| Synonyms | |
| SMILES | FC(C=C1C(NCC2=CC=C(OC)C(OCC#C)=C2)=O)=CC=C1N3CCOCC3 |
Biological Activity
| Description | Tubulin Polymerization-IN-1 prodrug is a palladium-mediated inhibitor of tubulin polymerization, developed to target the colchicine binding site. This prodrug demonstrates significantly reduced cytotoxicity compared to its parent compound, offering a 68.3-fold reduction in toxicity while maintaining effectiveness upon activation by Pd resin. Mechanistic investigations align its anticancer activity with that of colchicine binding site inhibitors. In vivo studies have shown that treatment with Tubulin Polymerization-IN-1 prodrug results in a substantial inhibition of tumor growth (63.2%) following Pd resin activation. This compound holds potential for advancing research in anticancer therapeutics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
