Product Data Sheet
ER degrader 7
Catalog No. A54932
ER Degrader 7 is a selective degrader of estrogen receptors ERα and ERβ, promoting their degradation to inhibit estrogen signaling. This compound demonstrates significant cytotoxicity in various breast cancer cell lines, with IC50 values of 0.06 µM in MCF-7, 2.56 µM in T47D, and varying values in other cell types. Additionally, ER Degrader 7 has been shown to impede tubulin polymerization, contributing to its effectiveness in inhibiting breast cancer tumor growth. This makes it a valuable tool for research into targeted therapies for hormone-driven malignancies.
Chemical Information
| Catalog Num | A54932 |
|---|---|
| M. Wt | 736.63 |
| Formula | C33H31F4N3O5SSe |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2922929-63-1 |
| Synonyms | |
| SMILES | O=C(CCCCC[Se]C#N)NC1=CC=C(C2=C(C3=CC=C(O)C=C3)[C@H]4CC(S(N(CC(F)(F)F)C5=C(F)C=CC=C5)(=O)=O)[C@@H]2O4)C=C1 |
Biological Activity
| Description | ER Degrader 7 is a selective degrader of estrogen receptors ERα and ERβ, promoting their degradation to inhibit estrogen signaling. This compound demonstrates significant cytotoxicity in various breast cancer cell lines, with IC50 values of 0.06 µM in MCF-7, 2.56 µM in T47D, and varying values in other cell types. Additionally, ER Degrader 7 has been shown to impede tubulin polymerization, contributing to its effectiveness in inhibiting breast cancer tumor growth. This makes it a valuable tool for research into targeted therapies for hormone-driven malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
