Product Data Sheet
ER-67880
Catalog No. A54947
ER-67880 is a potent microtubule inhibitor that disrupts microtubule dynamics with an IC50 of 9.5 μM. This compound demonstrates significant anti-proliferative effects against KB, Colon 38, and P338 cancer cell lines, with IC50 values of 0.55, 0.2, and 0.76 μg/mL, respectively. It causes G2/M phase cell cycle arrest and results in altered DNA replication patterns, alongside the down-regulation of G1 phase-related genes. ER-67880 is applicable in various cancer research studies, including those focused on nasopharyngeal carcinoma and murine adenocarcinoma.
Chemical Information
| Catalog Num | A54947 |
|---|---|
| M. Wt | 336.79 |
| Formula | C15H13ClN2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 247186-96-5 |
| Synonyms | |
| SMILES | O=S(C1=CC=C(C=C1)OC)(NC2=CC=CC3=C2NC=C3Cl)=O |
Biological Activity
| Description | ER-67880 is a potent microtubule inhibitor that disrupts microtubule dynamics with an IC50 of 9.5 μM. This compound demonstrates significant anti-proliferative effects against KB, Colon 38, and P338 cancer cell lines, with IC50 values of 0.55, 0.2, and 0.76 μg/mL, respectively. It causes G2/M phase cell cycle arrest and results in altered DNA replication patterns, alongside the down-regulation of G1 phase-related genes. ER-67880 is applicable in various cancer research studies, including those focused on nasopharyngeal carcinoma and murine adenocarcinoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
