Product Data Sheet
Breast cancer targeting peptide 18–4
Catalog No. A54954
Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide characterized by a binding affinity (Kd) of 0.98 μM. This peptide, with the amino acid sequence WxEAAYQrFL, serves as an analogue of the P160 peptide. When covalently conjugated with the anticancer peptide MccJ25, it significantly enhances the cellular uptake of MccJ25 in breast cancer cells, thereby improving its anticancer efficacy. The resulting conjugate demonstrates IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cell lines, respectively, making it valuable for research in breast cancer therapy.
Chemical Information
| Catalog Num | A54954 |
|---|---|
| M. Wt | 1296.47 |
| Formula | C63H89N15O15 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1332850-08-4 |
| Synonyms | |
| SMILES | C([C@@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)=O)C)=O)C)=O)CCC(O)=O)=O)CCCC)=O)N)C=3C=4C(NC3)=CC=CC4 |
Biological Activity
| Description | Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide characterized by a binding affinity (Kd) of 0.98 μM. This peptide, with the amino acid sequence WxEAAYQrFL, serves as an analogue of the P160 peptide. When covalently conjugated with the anticancer peptide MccJ25, it significantly enhances the cellular uptake of MccJ25 in breast cancer cells, thereby improving its anticancer efficacy. The resulting conjugate demonstrates IC50 values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cell lines, respectively, making it valuable for research in breast cancer therapy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
