Product Data Sheet
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
Catalog No. A55170
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer utilized for the synthesis of locked nucleic acid (LNA) analog oligonucleotides. This compound enhances hybridization affinity and mismatch discrimination with RNA due to its 2',4'-constrained ethyl modification, which locks the furanose ring in an N-type conformation. Its properties significantly improve resistance to exonuclease digestion and facilitate the formation of stable RNA hybrids that can mediate RNase H-dependent mRNA degradation or inhibit translation. Applications include the development of antisense oligonucleotides for gene expression regulation, gene function research, and the synthesis of oligonucleotides for therapeutic interventions.
Chemical Information
| Catalog Num | A55170 |
|---|---|
| M. Wt | 899.97 |
| Formula | C49H54N7O8P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1197033-19-4 |
| Synonyms | |
| SMILES | COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@]45[C@H]([C@](O[C@H]5C)([H])[C@H](N6C7=NC=NC(NC(C8=CC=CC=C8)=O)=C7N=C6)O4)OP(OCCC#N)N(C(C)C)C(C)C |
Biological Activity
| Description | 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer utilized for the synthesis of locked nucleic acid (LNA) analog oligonucleotides. This compound enhances hybridization affinity and mismatch discrimination with RNA due to its 2',4'-constrained ethyl modification, which locks the furanose ring in an N-type conformation. Its properties significantly improve resistance to exonuclease digestion and facilitate the formation of stable RNA hybrids that can mediate RNase H-dependent mRNA degradation or inhibit translation. Applications include the development of antisense oligonucleotides for gene expression regulation, gene function research, and the synthesis of oligonucleotides for therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
