Product Data Sheet
DFP-11207
Catalog No. A55396
DFP-11207 is an orally active fluoropyrimidine cytotoxic agent designed to target and enhance the pharmacological activity of 5-fluorouracil (5-FU). It functions as a pro-drug that incorporates a reversible dihydropyrimidine dehydrogenase (DPD) inhibitor and a potent orotate phosphoribosyltransferase (OPRT) inhibitor, which together mitigate gastrointestinal and myelosuppressive toxicities associated with traditional 5-FU therapy. DFP-11207 is primarily utilized in cancer research, providing insights into more effective and safer chemotherapeutic strategies.
Chemical Information
| Catalog Num | A55396 |
|---|---|
| M. Wt | 713.02 |
| Formula | C32H26ClFN4O12 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1296177-16-6 |
| Synonyms | |
| SMILES | O=C(C1=CC(OC(CC)=O)=NC(OC(CC)=O)=C1)OC2=CC(OC(C3=CC=CC(C(N(C(N(COCC)C=C4F)=O)C4=O)=O)=C3)=O)=NC=C2Cl |
Biological Activity
| Description | DFP-11207 is an orally active fluoropyrimidine cytotoxic agent designed to target and enhance the pharmacological activity of 5-fluorouracil (5-FU). It functions as a pro-drug that incorporates a reversible dihydropyrimidine dehydrogenase (DPD) inhibitor and a potent orotate phosphoribosyltransferase (OPRT) inhibitor, which together mitigate gastrointestinal and myelosuppressive toxicities associated with traditional 5-FU therapy. DFP-11207 is primarily utilized in cancer research, providing insights into more effective and safer chemotherapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
