Product Data Sheet
BJG-05-039
Catalog No. A56825
BJG-05-039 is a selective degrader of PAK1, formed by the conjugation of NVS-PAK1-1 and Lenalidomide. This compound effectively induces degradation of PAK1, resulting in the inhibition of MEK S298 and ERK phosphorylation. BJG-05-039 demonstrates notable anti-proliferative effects in PAK1-dependent cell lines, making it a valuable tool for research applications focused on PAK1-related signaling pathways and cancer biology.
Chemical Information
| Catalog Num | A56825 |
|---|---|
| M. Wt | 821.29 |
| Formula | C41H44ClF3N8O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3009849-06-0 |
| Synonyms | |
| SMILES | FC(F)CN1C2=C(C=C(Cl)C=C2)C(N[C@H]3CCN(C(NCCCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)=O)C3)=NC7=CC(F)=CC=C17 |
Biological Activity
| Description | BJG-05-039 is a selective degrader of PAK1, formed by the conjugation of NVS-PAK1-1 and Lenalidomide. This compound effectively induces degradation of PAK1, resulting in the inhibition of MEK S298 and ERK phosphorylation. BJG-05-039 demonstrates notable anti-proliferative effects in PAK1-dependent cell lines, making it a valuable tool for research applications focused on PAK1-related signaling pathways and cancer biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
