Product Data Sheet
HC-5404-Fu
Catalog No. A56863
HC-5404-Fu is a potent and orally active inhibitor of the protein kinase PERK, exhibiting an IC50 of 0.001 μM against human PERK. By blocking PERK activation induced by VEGFR-TKIs, HC-5404-Fu disrupts the adaptive stress response that typically enhances tumor survival. This compound enhances anti-angiogenic effects by inhibiting the formation of both newly formed and mature tumor blood vessels, particularly in renal cell carcinoma models. HC-5404-Fu is suitable for research focused on tumor biology and angiogenesis in renal cell carcinoma.
Chemical Information
| Catalog Num | A56863 |
|---|---|
| M. Wt | 512.51 |
| Formula | C24H24F2N4O3.1/2C4H4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3034479-99-4 |
| Synonyms | |
| SMILES | CC(C)NC(C1=CC(C2=CC=C(C=C2C)NC([C@@H](C3=CC(F)=CC(F)=C3)O)=O)=CN=C1N)=O.O=C(O)/C=C/C(O)=O.[1/2] |
Biological Activity
| Description | HC-5404-Fu is a potent and orally active inhibitor of the protein kinase PERK, exhibiting an IC50 of 0.001 μM against human PERK. By blocking PERK activation induced by VEGFR-TKIs, HC-5404-Fu disrupts the adaptive stress response that typically enhances tumor survival. This compound enhances anti-angiogenic effects by inhibiting the formation of both newly formed and mature tumor blood vessels, particularly in renal cell carcinoma models. HC-5404-Fu is suitable for research focused on tumor biology and angiogenesis in renal cell carcinoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
