Product Data Sheet
PERK-IN-5
Catalog No. A56867
PERK-IN-5 is a highly potent inhibitor of PERK (Protein kinase RNA-like endoplasmic reticulum kinase), demonstrating IC50 values of 2 nM and 9 nM for PERK and phosphorylated eIF2α, respectively. This compound is selectively and orally bioavailable, making it an advantageous tool for in vivo studies. PERK-IN-5 has been shown to significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft model, positioning it as a valuable reagent for cancer research focusing on the UPR (unfolded protein response) pathway.
Chemical Information
| Catalog Num | A56867 |
|---|---|
| M. Wt | 468.50 |
| Formula | C25H26F2N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2616821-91-9 |
| Synonyms | |
| SMILES | CCC1=C(C2=CN=C(N)C(C(NC(C)C)=O)=C2)C=CC(NC([C@@H](C3=CC(F)=CC(F)=C3)O)=O)=C1 |
Biological Activity
| Description | PERK-IN-5 is a highly potent inhibitor of PERK (Protein kinase RNA-like endoplasmic reticulum kinase), demonstrating IC50 values of 2 nM and 9 nM for PERK and phosphorylated eIF2α, respectively. This compound is selectively and orally bioavailable, making it an advantageous tool for in vivo studies. PERK-IN-5 has been shown to significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft model, positioning it as a valuable reagent for cancer research focusing on the UPR (unfolded protein response) pathway. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
