Product Data Sheet

PLK1-IN-2

Catalog No. A56906

main product photo
PLK1-IN-2 is a potent inhibitor of the polo-like kinase 1 (PLK1), exhibiting an IC50 value of 0.384 μM. This compound disrupts PLK1 activity, which is crucial for regulating cell division and cancer cell proliferation. It is primarily utilized in cancer research to investigate the role of PLK1 in tumorigenesis and to assess its potential as a therapeutic target.
Chemical Information
Catalog NumA56906
M. Wt494.59
FormulaC24H27FN8OS
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.2640254-52-8
Synonyms
SMILESCN(CC1)CCN1C2=CC=C(NC3=NC(N(C4=NC(N=S(C)(C)=O)=CC=C4)C=C5F)=C5C=N3)C=C2
Biological Activity
DescriptionPLK1-IN-2 is a potent inhibitor of the polo-like kinase 1 (PLK1), exhibiting an IC50 value of 0.384 μM. This compound disrupts PLK1 activity, which is crucial for regulating cell division and cancer cell proliferation. It is primarily utilized in cancer research to investigate the role of PLK1 in tumorigenesis and to assess its potential as a therapeutic target.
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