Product Data Sheet
PDD00017238
Catalog No. A56919
PDD00017238 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), demonstrating EC50 values of 40 nM in biochemical assays and 55 nM in cellular assays. This compound effectively disrupts the enzymatic activity of PARG, leading to the accumulation of poly(ADP-ribose) chains and influencing DNA repair mechanisms. PDD00017238 is useful for studying the role of PARG in cellular processes, particularly in the context of DNA damage response and potential therapeutic strategies in oncology.
Chemical Information
| Catalog Num | A56919 |
|---|---|
| M. Wt | 476.60 |
| Formula | C19H20N6O3S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1952247-05-0 |
| Synonyms | |
| SMILES | O=S(C1=CC=C(N2CC3=C(C)N=C(C)S3)C(N(C4=NC=NS4)C2=O)=C1)(NC5(C)CC5)=O |
Biological Activity
| Description | PDD00017238 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), demonstrating EC50 values of 40 nM in biochemical assays and 55 nM in cellular assays. This compound effectively disrupts the enzymatic activity of PARG, leading to the accumulation of poly(ADP-ribose) chains and influencing DNA repair mechanisms. PDD00017238 is useful for studying the role of PARG in cellular processes, particularly in the context of DNA damage response and potential therapeutic strategies in oncology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
