Product Data Sheet
Cholesterol sulfate
Catalog No. A56956
Cholesterol sulfate is a naturally occurring cholesterol derivative that functions as a DOCK2 inhibitor, exhibiting IC50 values of 2 μM for mouse targets and 2.9 μM for human targets. This compound shows significant anti-inflammatory activity by limiting neutrophil infiltration and mitigating intestinal inflammation and damage. Additionally, it activates protein kinase C (PKC), facilitating squamous cell differentiation and inhibiting skin carcinogenesis. Cholesterol sulfate is relevant for research applications in conditions such as actinic keratitis, ulcerative colitis, and skin cancer, and it plays a role in regulating cholesterol homeostasis and cellular metabolism via the AMPK-Sirt1 pathway.
Chemical Information
| Catalog Num | A56956 |
|---|---|
| M. Wt | 466.72 |
| Formula | C27H46O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1256-86-6 |
| Synonyms | |
| SMILES | CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OS(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
Biological Activity
| Description | Cholesterol sulfate is a naturally occurring cholesterol derivative that functions as a DOCK2 inhibitor, exhibiting IC50 values of 2 μM for mouse targets and 2.9 μM for human targets. This compound shows significant anti-inflammatory activity by limiting neutrophil infiltration and mitigating intestinal inflammation and damage. Additionally, it activates protein kinase C (PKC), facilitating squamous cell differentiation and inhibiting skin carcinogenesis. Cholesterol sulfate is relevant for research applications in conditions such as actinic keratitis, ulcerative colitis, and skin cancer, and it plays a role in regulating cholesterol homeostasis and cellular metabolism via the AMPK-Sirt1 pathway. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
