Product Data Sheet
E1231
Catalog No. A56962
E1231 is a potent activator of Sirtuin 1 (SIRT1), exhibiting an EC50 of 0.83 μM. This compound enhances cholesterol and lipid metabolism by interacting with SIRT1 (KD = 9.61 μM) and promoting the deacetylation of liver X receptor-alpha (LXRα), which subsequently increases the expression of ATP-binding cassette transporter A1 (ABCA1). Additionally, E1231 has demonstrated efficacy in reducing atherosclerotic plaque development in ApoE-/- mouse models, making it a valuable tool for research into lipid disorders and related diseases.
Chemical Information
| Catalog Num | A56962 |
|---|---|
| M. Wt | 363.41 |
| Formula | C21H21N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1031195-19-3 |
| Synonyms | 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one |
| SMILES | CC(N1CCN(C(C2=CC(C3=CC=C(C)O3)=NC4=CC=CC=C24)=O)CC1)=O |
Biological Activity
| Description | E1231 is a potent activator of Sirtuin 1 (SIRT1), exhibiting an EC50 of 0.83 μM. This compound enhances cholesterol and lipid metabolism by interacting with SIRT1 (KD = 9.61 μM) and promoting the deacetylation of liver X receptor-alpha (LXRα), which subsequently increases the expression of ATP-binding cassette transporter A1 (ABCA1). Additionally, E1231 has demonstrated efficacy in reducing atherosclerotic plaque development in ApoE-/- mouse models, making it a valuable tool for research into lipid disorders and related diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
