Product Data Sheet
(1S,9R)-Exatecan mesylate
Catalog No. A57086
(1S,9R)-Exatecan mesylate is a potent topoisomerase I inhibitor that acts by stabilizing the enzyme-DNA cleavable complex, thereby blocking enzyme activity and inducing apoptosis. With an IC50 value of 0.975 μg/mL in mice and 0.82 μg/mL in humans, this non-prodrug camptothecin derivative effectively inhibits the proliferation of various malignant tumor cells and tumor growth while overcoming P-glycoprotein-mediated multidrug resistance. (1S,9R)-Exatecan mesylate is utilized in preclinical studies on multiple cancers, including pancreatic, lung, breast cancers, and leukemia.
Chemical Information
| Catalog Num | A57086 |
|---|---|
| M. Wt | 531.55 |
| Formula | C25H26FN3O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2938875-54-6 |
| Synonyms | (1S,9R)-DX8951f |
| SMILES | O=S(C)(O)=O.O=C1[C@@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O |
Biological Activity
| Description | (1S,9R)-Exatecan mesylate is a potent topoisomerase I inhibitor that acts by stabilizing the enzyme-DNA cleavable complex, thereby blocking enzyme activity and inducing apoptosis. With an IC50 value of 0.975 μg/mL in mice and 0.82 μg/mL in humans, this non-prodrug camptothecin derivative effectively inhibits the proliferation of various malignant tumor cells and tumor growth while overcoming P-glycoprotein-mediated multidrug resistance. (1S,9R)-Exatecan mesylate is utilized in preclinical studies on multiple cancers, including pancreatic, lung, breast cancers, and leukemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
