Product Data Sheet
PNU-142586
Catalog No. A57118
PNU-142586 is an inhibitor of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B) that serves as a major metabolite of Linezolid. By obstructing the binding of DNA to topoisomerases and inhibiting ATP hydrolysis, PNU-142586 disrupts DNA replication and transcription, leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. This compound is valuable for investigating Linezolid-induced hematotoxicity and elucidating its underlying molecular mechanisms.
Chemical Information
| Catalog Num | A57118 |
|---|---|
| M. Wt | 369.34 |
| Formula | C16H20FN3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 368891-70-7 |
| Synonyms | |
| SMILES | O=C(CN(CCO)C1=CC=C(C=C1F)N2C(O[C@H](C2)CNC(C)=O)=O)O |
Biological Activity
| Description | PNU-142586 is an inhibitor of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B) that serves as a major metabolite of Linezolid. By obstructing the binding of DNA to topoisomerases and inhibiting ATP hydrolysis, PNU-142586 disrupts DNA replication and transcription, leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. This compound is valuable for investigating Linezolid-induced hematotoxicity and elucidating its underlying molecular mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
