Product Data Sheet
Indotecan hydrochloride
Catalog No. A57123
Indotecan hydrochloride is a potent inhibitor of Topoisomerase I, demonstrating IC50 values of 300, 1200, and 560 nM in P388, HCT116, and MCF-7 cell lines, respectively. This indenoisoquinoline derivative functions by preventing the relaxation of supercoiled DNA, thus interfering with DNA replication and transcription processes. Indotecan hydrochloride has potential applications in cancer research and is also relevant in the study of visceral leishmaniasis.
Chemical Information
| Catalog Num | A57123 |
|---|---|
| M. Wt | 514.95 |
| Formula | C26H27ClN2O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1228035-68-4 |
| Synonyms | LMP-400 hydrochloride; NSC-724998 hydrochloride |
| SMILES | O=C1C2=C(C3=C1C4=CC(OC)=C(C=C4C(N3CCCN5CCOCC5)=O)OC)C=C6OCOC6=C2.Cl |
Biological Activity
| Description | Indotecan hydrochloride is a potent inhibitor of Topoisomerase I, demonstrating IC50 values of 300, 1200, and 560 nM in P388, HCT116, and MCF-7 cell lines, respectively. This indenoisoquinoline derivative functions by preventing the relaxation of supercoiled DNA, thus interfering with DNA replication and transcription processes. Indotecan hydrochloride has potential applications in cancer research and is also relevant in the study of visceral leishmaniasis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
