Product Data Sheet
XR11576
Catalog No. A57140
XR11576 is an orally active inhibitor of topoisomerase I and II, demonstrating significant cytotoxicity against both human and murine tumor cell lines, with IC50 values ranging from 6 to 47 nM. This compound is primarily utilized in cancer research to explore the mechanisms of DNA replication and repair, making it a valuable tool for investigations into anticancer therapies and the underlying biology of tumor cells.
Chemical Information
| Catalog Num | A57140 |
|---|---|
| M. Wt | 388.46 |
| Formula | C23H24N4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 346689-77-8 |
| Synonyms | MLN576 |
| SMILES | O=C(N[C@@H](CN(C)C)C)C1=C2C(N=C3C=CC4=C(C=CC=C4C3=N2)OC)=CC=C1 |
Biological Activity
| Description | XR11576 is an orally active inhibitor of topoisomerase I and II, demonstrating significant cytotoxicity against both human and murine tumor cell lines, with IC50 values ranging from 6 to 47 nM. This compound is primarily utilized in cancer research to explore the mechanisms of DNA replication and repair, making it a valuable tool for investigations into anticancer therapies and the underlying biology of tumor cells. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
