Product Data Sheet
PNU-142586 sodium
Catalog No. A57159
PNU-142586 sodium is a potent inhibitor of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). This compound effectively disrupts DNA replication and transcription by preventing the binding of DNA to TOP2 and inhibiting ATP hydrolysis, resulting in antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 sodium is primarily utilized in research investigating Linezolid-induced hematotoxicity and its underlying molecular mechanisms.
Chemical Information
| Catalog Num | A57159 |
|---|---|
| M. Wt | 391.33 |
| Formula | C16H19FN3NaO6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2468637-62-7 |
| Synonyms | |
| SMILES | O=C(CN(CCO)C1=CC=C(C=C1F)N2C(O[C@H](C2)CNC(C)=O)=O)O[Na] |
Biological Activity
| Description | PNU-142586 sodium is a potent inhibitor of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). This compound effectively disrupts DNA replication and transcription by preventing the binding of DNA to TOP2 and inhibiting ATP hydrolysis, resulting in antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 sodium is primarily utilized in research investigating Linezolid-induced hematotoxicity and its underlying molecular mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
