Product Data Sheet
Anticancer agent 216
Catalog No. A57166
Anticancer agent 216 (34A) is a Camptothecin derivative that selectively inhibits topoisomerase I, disrupting DNA replication and transcription. It demonstrates potent cytotoxicity with IC50 values of 9.6 nM in MCF-7 breast cancer cells and 11.6 nM in MDA-MB-231 cells. This compound is valuable for research applications focused on developing targeted therapies for breast cancer and understanding the mechanisms of tumor cell resistance.
Chemical Information
| Catalog Num | A57166 |
|---|---|
| M. Wt | 435.43 |
| Formula | C23H21N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2916406-02-3 |
| Synonyms | |
| SMILES | C[C@@H](C1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC(OCO6)=C6C=C51)N |
Biological Activity
| Description | Anticancer agent 216 (34A) is a Camptothecin derivative that selectively inhibits topoisomerase I, disrupting DNA replication and transcription. It demonstrates potent cytotoxicity with IC50 values of 9.6 nM in MCF-7 breast cancer cells and 11.6 nM in MDA-MB-231 cells. This compound is valuable for research applications focused on developing targeted therapies for breast cancer and understanding the mechanisms of tumor cell resistance. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
