Product Data Sheet
cis-THSG
Catalog No. A57169
cis-THSG is a selective inhibitor of DNA topoisomerase II, demonstrating no activity against DNA topoisomerase I. This compound effectively suppresses the transcription of phosphoenolpyruvate carboxykinase (PEPCK), leading to reductions in blood glucose levels, improvement of glucose intolerance, and alleviation of insulin resistance in high-fat diet-induced diabetic male CF-1 mice. cis-THSG serves as a valuable tool for research into type 2 diabetes mellitus and the mechanisms of glucose metabolism.
Chemical Information
| Catalog Num | A57169 |
|---|---|
| M. Wt | 406.38 |
| Formula | C20H22O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 928205-59-8 |
| Synonyms | |
| SMILES | O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=C(/C=C\C3=CC=C(O)C=C3)C=C(O)C=C2O |
Biological Activity
| Description | cis-THSG is a selective inhibitor of DNA topoisomerase II, demonstrating no activity against DNA topoisomerase I. This compound effectively suppresses the transcription of phosphoenolpyruvate carboxykinase (PEPCK), leading to reductions in blood glucose levels, improvement of glucose intolerance, and alleviation of insulin resistance in high-fat diet-induced diabetic male CF-1 mice. cis-THSG serves as a valuable tool for research into type 2 diabetes mellitus and the mechanisms of glucose metabolism. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
