Product Data Sheet
(R)-Amrubicin
Catalog No. A57200
(R)-Amrubicin is a topoisomerase II inhibitor and an anthracycline derivative that intercalates into DNA, effectively disrupting DNA replication and impeding RNA and protein synthesis. This results in significant inhibition of cell growth and induction of apoptosis, making it a promising candidate for lung cancer treatment. Notably, (R)-Amrubicin demonstrates enhanced anti-tumor efficacy relative to traditional anthracyclines and exhibits a reduced risk of cumulative cardiac toxicity, providing a safer alternative for cancer therapy.
Chemical Information
| Catalog Num | A57200 |
|---|---|
| M. Wt | 483.47 |
| Formula | C25H25NO9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 92395-36-3 |
| Synonyms | (R)-SM-5887 |
| SMILES | CC([C@@](C1)(N)C[C@H](O[C@H]2OC[C@@H](O)[C@@H](O)C2)C(C1=C3O)=C(O)C4=C3C(C5=CC=CC=C5C4=O)=O)=O |
Biological Activity
| Description | (R)-Amrubicin is a topoisomerase II inhibitor and an anthracycline derivative that intercalates into DNA, effectively disrupting DNA replication and impeding RNA and protein synthesis. This results in significant inhibition of cell growth and induction of apoptosis, making it a promising candidate for lung cancer treatment. Notably, (R)-Amrubicin demonstrates enhanced anti-tumor efficacy relative to traditional anthracyclines and exhibits a reduced risk of cumulative cardiac toxicity, providing a safer alternative for cancer therapy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
