Product Data Sheet
NU/ICRF 500
Catalog No. A57230
NU/ICRF 500 is a potent inhibitor of topoisomerase II catalytic activity, critical for DNA replication and repair. This compound has been shown to increase the formation of CREST-negative micronuclei in human lymphocytes, highlighting its role in genotoxicity studies and cancer research. It serves as a valuable tool for investigating the mechanisms of DNA damage and the effects of topoisomerase inhibition in various biological contexts.
Chemical Information
| Catalog Num | A57230 |
|---|---|
| M. Wt | 341.32 |
| Formula | C17H15N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 156074-08-7 |
| Synonyms | |
| SMILES | OC[C@H](NC1=C(C2=O)C(C(C3=C2C=CC=C3)=O)=C(O)C=C1)C(NN)=O |
Biological Activity
| Description | NU/ICRF 500 is a potent inhibitor of topoisomerase II catalytic activity, critical for DNA replication and repair. This compound has been shown to increase the formation of CREST-negative micronuclei in human lymphocytes, highlighting its role in genotoxicity studies and cancer research. It serves as a valuable tool for investigating the mechanisms of DNA damage and the effects of topoisomerase inhibition in various biological contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
