Product Data Sheet
LEB-03-146
Catalog No. A57243
LEB-03-146 is a WEE1 deubiquitinase-targeting chimera (DUBTAC) that conjugates the potent inhibitor AZD1775 (Adavosertib) with the recruiter EN523 via a PEG2 linker. This compound effectively stabilizes WEE1 in HEP3B hepatoma cancer cells, making it a valuable tool for research into cell cycle regulation and cancer therapy. Its unique mechanism of action offers potential for novel therapeutic strategies in oncology.
Chemical Information
| Catalog Num | A57243 |
|---|---|
| M. Wt | 892.01 |
| Formula | C46H57N11O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2858812-91-4 |
| Synonyms | |
| SMILES | C=CCN1C(C2=C(N1C3=NC(C(C)(O)C)=CC=C3)N=C(N=C2)NC4=CC=C(C=C4)N5CCN(CC5)CCOCCOCCNC(CCC6=CC=C(O6)N7CCN(CC7=O)C(C=C)=O)=O)=O |
Biological Activity
| Description | LEB-03-146 is a WEE1 deubiquitinase-targeting chimera (DUBTAC) that conjugates the potent inhibitor AZD1775 (Adavosertib) with the recruiter EN523 via a PEG2 linker. This compound effectively stabilizes WEE1 in HEP3B hepatoma cancer cells, making it a valuable tool for research into cell cycle regulation and cancer therapy. Its unique mechanism of action offers potential for novel therapeutic strategies in oncology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
