Product Data Sheet
PKMYT1-IN-8
Catalog No. A57246
PKMYT1-IN-8 is a specific inhibitor of PKMYT1, demonstrating an IC50 of 9 nM. In addition to its primary target, it also inhibits several receptor tyrosine kinases, including EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2, with varying IC50 values ranging from 1.79 to 10.9 μM. This compound effectively reduces the proliferation of the OVCAR3 cancer cell line, exhibiting a GI50 of 2.02 μM. PKMYT1-IN-8 is useful for research focused on cancer biology and targeted therapies.
Chemical Information
| Catalog Num | A57246 |
|---|---|
| M. Wt | 379.34 |
| Formula | C17H16F3N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3065631-84-4 |
| Synonyms | |
| SMILES | CC1=NC(C(F)(F)F)=C2C(N(C3=C(C)C=CC(O)=C3C)C(N)=C2C(N)=O)=N1 |
Biological Activity
| Description | PKMYT1-IN-8 is a specific inhibitor of PKMYT1, demonstrating an IC50 of 9 nM. In addition to its primary target, it also inhibits several receptor tyrosine kinases, including EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2, with varying IC50 values ranging from 1.79 to 10.9 μM. This compound effectively reduces the proliferation of the OVCAR3 cancer cell line, exhibiting a GI50 of 2.02 μM. PKMYT1-IN-8 is useful for research focused on cancer biology and targeted therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
