Product Data Sheet
LEB-03-145
Catalog No. A57264
LEB-03-145 is a WEE1 deubiquitinase-targeting chimera (DUBTAC) that effectively links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 via a C5 alkyl linker. This compound enhances the stability and activity of AZD1775 by modulating ubiquitination processes. LEB-03-145 is valuable for studying WEE1 regulation and offers potential in cancer research, particularly in the context of targeting tumor cell proliferation and survival pathways.
Chemical Information
| Catalog Num | A57264 |
|---|---|
| M. Wt | 845.99 |
| Formula | C45H55N11O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2858812-90-3 |
| Synonyms | |
| SMILES | C=CCN1C(C2=C(N1C3=NC(C(C)(O)C)=CC=C3)N=C(N=C2)NC4=CC=C(C=C4)N5CCN(CC5)CCCCCNC(CCC6=CC=C(O6)N7CCN(CC7=O)C(C=C)=O)=O)=O |
Biological Activity
| Description | LEB-03-145 is a WEE1 deubiquitinase-targeting chimera (DUBTAC) that effectively links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 via a C5 alkyl linker. This compound enhances the stability and activity of AZD1775 by modulating ubiquitination processes. LEB-03-145 is valuable for studying WEE1 regulation and offers potential in cancer research, particularly in the context of targeting tumor cell proliferation and survival pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
