Product Data Sheet
WEE1-IN-11
Catalog No. A57268
WEE1-IN-11 is a potent inhibitor of the Wee1 kinase, demonstrating an impressive IC50 of 2.0 nM against CDK2. This compound effectively inhibits various cancer cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with IC50 values of 93.9 nM, 34.5 nM, 86.7 nM, 23.1 nM, and 85 nM, respectively. It serves as a valuable tool for investigating cell cycle regulation and the therapeutic potential of targeting Wee1 in cancer research.
Chemical Information
| Catalog Num | A57268 |
|---|---|
| M. Wt | 552.69 |
| Formula | C26H29FN8OS2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2975172-98-4 |
| Synonyms | |
| SMILES | CN1CCN(C2=CC=C(NC3=NC=C(C4=CN=CS4)C(C5=CN=C(N6C[C@@H](F)CC6)S5)=N3)C=C2OC)CC1 |
Biological Activity
| Description | WEE1-IN-11 is a potent inhibitor of the Wee1 kinase, demonstrating an impressive IC50 of 2.0 nM against CDK2. This compound effectively inhibits various cancer cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with IC50 values of 93.9 nM, 34.5 nM, 86.7 nM, 23.1 nM, and 85 nM, respectively. It serves as a valuable tool for investigating cell cycle regulation and the therapeutic potential of targeting Wee1 in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
