Product Data Sheet
LXY3
Catalog No. A57458
LXY3 is a VLA-3-blocking peptide that inhibits the interaction between the integrin α3β1 (VLA-3) present on neutrophils and laminin in the basement membrane. By obstructing this interaction, LXY3 effectively prevents neutrophil migration across the tumor vascular basement membrane barrier, thereby mitigating neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. This peptide is particularly useful in targeted imaging studies related to breast cancer.
Chemical Information
| Catalog Num | A57458 |
|---|---|
| M. Wt | 885.88 |
| Formula | C32H43N11O15S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1095009-44-1 |
| Synonyms | LXY2 |
| SMILES | O=C1[C@]2(N(C[C@H](O)C2)C(=O)CNC(=O)[C@H](CC3=CC(N(=O)=O)=C(O)C=C3)NC(=O)CNC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](N)CSSC[C@H](C(N)=O)NC(=O)[C@H](CC(N)=O)N1)[H] |
Biological Activity
| Description | LXY3 is a VLA-3-blocking peptide that inhibits the interaction between the integrin α3β1 (VLA-3) present on neutrophils and laminin in the basement membrane. By obstructing this interaction, LXY3 effectively prevents neutrophil migration across the tumor vascular basement membrane barrier, thereby mitigating neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. This peptide is particularly useful in targeted imaging studies related to breast cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
