Product Data Sheet
Bexotegrast hydrochloride
Catalog No. A57467
Bexotegrast hydrochloride is a selective dual inhibitor of the αvβ1 and αvβ6 integrins. By inhibiting these integrins, Bexotegrast hydrochloride effectively blocks the activation of TGF-β1, which is crucial in preventing the fibrotic growth in tissues associated with idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). This compound serves as a valuable tool for research into fibrosis-related pathologies and therapeutic interventions for fibrotic diseases.
Chemical Information
| Catalog Num | A57467 |
|---|---|
| M. Wt | 565.54 |
| Formula | C27H38Cl2N6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2775365-40-5 |
| Synonyms | PLN-74809 hydrochloride |
| SMILES | COCCN(CCCCC(N1)=CC=C2C1=NCCC2)CC[C@@H](C(O)=O)NC3=NC=NC4=C3C=CC=C4.Cl.Cl |
Biological Activity
| Description | Bexotegrast hydrochloride is a selective dual inhibitor of the αvβ1 and αvβ6 integrins. By inhibiting these integrins, Bexotegrast hydrochloride effectively blocks the activation of TGF-β1, which is crucial in preventing the fibrotic growth in tissues associated with idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). This compound serves as a valuable tool for research into fibrosis-related pathologies and therapeutic interventions for fibrotic diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
