Product Data Sheet
GW559090
Catalog No. A57479
GW559090 is a selective α4 integrin antagonist that competitively inhibits α4β1 with a Kd of 0.19 nM. It effectively disrupts the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, with IC50 values of 7.72 nM and 8.04 nM, respectively. Additionally, GW559090 inhibits the α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) interaction (IC50 = 23 nM). This compound has potential applications in research focused on inflammatory conditions such as Sjögren's syndrome and related dry eye disorders.
Chemical Information
| Catalog Num | A57479 |
|---|---|
| M. Wt | 596.67 |
| Formula | C31H40N4O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 278598-52-0 |
| Synonyms | |
| SMILES | O=C(O)[C@H](CC1=CC=C(OC(N2CCC(C(N)=O)CC2)=O)C=C1)NC([C@H](CC(C)C)NC(COC3=CC=CC=C3C)=O)=O |
Biological Activity
| Description | GW559090 is a selective α4 integrin antagonist that competitively inhibits α4β1 with a Kd of 0.19 nM. It effectively disrupts the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, with IC50 values of 7.72 nM and 8.04 nM, respectively. Additionally, GW559090 inhibits the α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) interaction (IC50 = 23 nM). This compound has potential applications in research focused on inflammatory conditions such as Sjögren's syndrome and related dry eye disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
