Product Data Sheet
α4 integrin receptor antagonist 3
Catalog No. A57485
α4 integrin receptor antagonist 3 is a potent orally active antagonist of the α4 integrin receptor. It effectively inhibits the adhesion of K562 cells through the α4β1/VCAM-1 and α4β7/MAdCAM-1 interactions, demonstrating IC50 values of 130 nM and 2 nM, respectively. This compound is suitable for research applications involving inflammatory disorders and may be particularly useful in the study of dextran sulfate sodium (DSS) colitis models.
Chemical Information
| Catalog Num | A57485 |
|---|---|
| M. Wt | 506.34 |
| Formula | C23H21Cl2N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 863226-74-8 |
| Synonyms | |
| SMILES | COC1=C(C2=CC=C(C=C2)C[C@@H](C(O)=O)NC(C3=C(C=CC=C3Cl)Cl)=O)C(N(N=C1)CCO)=O |
Biological Activity
| Description | α4 integrin receptor antagonist 3 is a potent orally active antagonist of the α4 integrin receptor. It effectively inhibits the adhesion of K562 cells through the α4β1/VCAM-1 and α4β7/MAdCAM-1 interactions, demonstrating IC50 values of 130 nM and 2 nM, respectively. This compound is suitable for research applications involving inflammatory disorders and may be particularly useful in the study of dextran sulfate sodium (DSS) colitis models. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
