Product Data Sheet
α5β1 integrin-IN-1
Catalog No. A57487
α5β1 integrin-IN-1 is a highly selective inhibitor of the α5β1 integrin, demonstrating a pIC50 of 9.4 and over 10,000-fold selectivity for α5β1 compared to αVβ3 (pIC50 = 5.5). This compound effectively reduces airway smooth muscle tension by disrupting cellular tethering mechanisms. With favorable inhalation pharmacokinetics in rodent models, α5β1 integrin-IN-1 is a valuable tool for researchers investigating asthma and related respiratory conditions.
Chemical Information
| Catalog Num | A57487 |
|---|---|
| M. Wt | 629.47 |
| Formula | C29H27Cl2FN6O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2649899-08-9 |
| Synonyms | |
| SMILES | ClC1=C(C(N[C@@H](CNC(CNC(C2=CC(NC3=NCC(F)CN3)=CC=C2)=O)=O)C(O)=O)=O)C(Cl)=CC(C4=CC=CC=C4)=C1 |
Biological Activity
| Description | α5β1 integrin-IN-1 is a highly selective inhibitor of the α5β1 integrin, demonstrating a pIC50 of 9.4 and over 10,000-fold selectivity for α5β1 compared to αVβ3 (pIC50 = 5.5). This compound effectively reduces airway smooth muscle tension by disrupting cellular tethering mechanisms. With favorable inhalation pharmacokinetics in rodent models, α5β1 integrin-IN-1 is a valuable tool for researchers investigating asthma and related respiratory conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
