Product Data Sheet
BTT-3034
Catalog No. A57498
BTT-3034 is a sulfonamide derivative that selectively inhibits the α2β1 integrin, targeting its role in cell adhesion. It demonstrates significant biological activity by inhibiting cell adhesion to rat tail collagen I with an EC50 of 160 nM and a maximal effect of 86%. Additionally, BTT-3034 effectively inhibits collagen binding in an α2 integrin variant that carries the conformationally activating E318W mutation, making it a valuable tool for research in cellular adhesion and integrin biology.
Chemical Information
| Catalog Num | A57498 |
|---|---|
| M. Wt | 467.56 |
| Formula | C22H21N5O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1259029-47-4 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(N(S(=O)(C2=CC=C(C3=CC=NN3C)S2)=O)C)C=C1)NC4=CC=CC=C4 |
Biological Activity
| Description | BTT-3034 is a sulfonamide derivative that selectively inhibits the α2β1 integrin, targeting its role in cell adhesion. It demonstrates significant biological activity by inhibiting cell adhesion to rat tail collagen I with an EC50 of 160 nM and a maximal effect of 86%. Additionally, BTT-3034 effectively inhibits collagen binding in an α2 integrin variant that carries the conformationally activating E318W mutation, making it a valuable tool for research in cellular adhesion and integrin biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
