Product Data Sheet
PXL770
Catalog No. A57630
PXL770 is a selective allosteric activator of AMP-activated protein kinase (AMPK) that enhances metabolic regulation. It has been shown to decrease very long-chain fatty acid (VLCFA) levels, improve mitochondrial respiration, and modulate gene expression in proinflammatory pathways in fibroblasts and lymphocytes related to X-linked adrenoleukodystrophy (ALD). In animal models, PXL770 normalizes plasma VLCFA levels and improves metabolic parameters such as glycemia and insulin sensitivity in diet-induced obesity. This compound serves as a valuable tool for research into ALD, autosomal dominant polycystic kidney disease, and nonalcoholic steatohepatitis (NASH).
Chemical Information
| Catalog Num | A57630 |
|---|---|
| M. Wt | 423.91 |
| Formula | C23H18ClNO3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1523493-53-9 |
| Synonyms | |
| SMILES | O=C1NC2=C(C(O)=C1C3=CC=CC=C3)C(C4=C(O)C(CCCC5)=C5C=C4)=C(Cl)S2 |
Biological Activity
| Description | PXL770 is a selective allosteric activator of AMP-activated protein kinase (AMPK) that enhances metabolic regulation. It has been shown to decrease very long-chain fatty acid (VLCFA) levels, improve mitochondrial respiration, and modulate gene expression in proinflammatory pathways in fibroblasts and lymphocytes related to X-linked adrenoleukodystrophy (ALD). In animal models, PXL770 normalizes plasma VLCFA levels and improves metabolic parameters such as glycemia and insulin sensitivity in diet-induced obesity. This compound serves as a valuable tool for research into ALD, autosomal dominant polycystic kidney disease, and nonalcoholic steatohepatitis (NASH). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
