Product Data Sheet
GSK3735967
Catalog No. A57700
GSK3735967 is a selective, reversible inhibitor of DNA methyltransferase 1 (DNMT1), demonstrating an IC50 value of 40 nM. Featuring a planar dicyanopyridine core, GSK3735967 specifically targets DNMT1 when bound to hemimethylated CpG dinucleotides. Its unique three-binding site configuration allows for interaction with histone H4K20me3, facilitating research into epigenetic regulation and potential therapeutic applications in cancer and other diseases associated with aberrant DNA methylation.
Chemical Information
| Catalog Num | A57700 |
|---|---|
| M. Wt | 477.62 |
| Formula | C25H31N7OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2170136-86-2 |
| Synonyms | |
| SMILES | N#CC1=C(SCC2=CC=C(CNC(CN)=O)C=C2)N=C(N3CCN(CCC3)C)C(C#N)=C1CC |
Biological Activity
| Description | GSK3735967 is a selective, reversible inhibitor of DNA methyltransferase 1 (DNMT1), demonstrating an IC50 value of 40 nM. Featuring a planar dicyanopyridine core, GSK3735967 specifically targets DNMT1 when bound to hemimethylated CpG dinucleotides. Its unique three-binding site configuration allows for interaction with histone H4K20me3, facilitating research into epigenetic regulation and potential therapeutic applications in cancer and other diseases associated with aberrant DNA methylation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
